Toxic protein clumps can prevent their own disassembly
Oligomers are aggregates made up of a small number of protein molecules. In the case of Alzheimer's disease, for example, this is the protein amyloid beta (Aβ). Apart from oligomers, larger structures can also develop out of these proteins, i.e. fibrils and ultimately plaques, which form from fibrils. All these substances are toxic to nerve cells. It is already known that the oligomers are the most dangerous, since even in very small quantities they damage or even kill off nerve cells.
